In healthy individuals, the kidneys play a major role in eliminating waste products generated from metabolic processes, as well as in controlling the levels of various electrolytes. Within the field of minerals, the kidneys maintain the balance of phosphate and calcium. Both elements have multiple crucial functions in the organism. Very well known is their interaction in the structuring of bone mass and therefore in the support of bone stability.
As renal disease progresses the metabolism of calcium and phosphorus could not be balanced any longer so that e.g. the phosphate level in blood increases higher than normal (hyperphosphataemia). As a consequence patients with CKD may develop renal bone disease.